Journal Article

Applications of genomic microarrays to explore human chromosome structure and function

Nigel P. Carter and David Vetrie

in Human Molecular Genetics

Volume 13, issue suppl_2, pages R297-R302
Published in print October 2004 | ISSN: 0964-6906
Published online October 2004 | e-ISSN: 1460-2083 | DOI: http://dx.doi.org/10.1093/hmg/ddh230
Applications of genomic microarrays to explore human chromosome structure and function

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The combination of genomic microarrays with comparative genomic hybridization and with chromatin immunoprecipitation is providing an increasingly detailed view of the way in which the human genome is organized and functions and how disorganization and disfunction can lead to disease. These studies are enhanced by the flexibility of array technology, allowing resolutions from coverage of the whole genome using 200 kb cloned DNA inserts to detailed analysis using PCR products or oligonucleotides of 100 bp or less. In particular, the use of chromatin immunoprecipitation is providing new insights into chromosome structure and gene regulation and control through the analysis of protein–DNA interactions.

Journal Article.  4659 words.  Illustrated.

Subjects: Genetics and Genomics

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