Journal Article

Frataxin interacts functionally with mitochondrial electron transport chain proteins

Pilar González-Cabo, Rafael P. Vázquez-Manrique, M. Adelaida García-Gimeno, Pascual Sanz and Francesc Palau

in Human Molecular Genetics

Volume 14, issue 15, pages 2091-2098
Published in print August 2005 | ISSN: 0964-6906
Published online June 2005 | e-ISSN: 1460-2083 | DOI:
Frataxin interacts functionally with mitochondrial electron transport chain proteins

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Frataxin deficiency is the main cause of Friedreich ataxia, an autosomal recessive neurodegenerative disorder. Frataxin function in mitochondria has not been fully explained yet. In this work, we show that Saccharomyces cerevisiae frataxin orthologue Yfh1p interacts physically with succinate dehydrogenase complex subunits Sdh1p and Sdh2p of the yeast mitochondrial electron transport chain and also with electron transfer flavoprotein complex ETFα and ETFβ subunits from the electron transfer flavoprotein complex. Genetic synthetic interaction experiments confirmed a functional relationship between YFH1 and succinate dehydrogenase genes SDH1 and SDH2. We also demonstrate a physical interaction between human frataxin and human succinate dehydrogenase complex subunits, suggesting also a key role of frataxin in the mitochondrial electron transport chain in humans. Consequently, we suggest a direct participation of the respiratory chain in the pathogenesis of the Friedreich ataxia, which we propose to be considered as an OXPHOS disease.

Journal Article.  5328 words.  Illustrated.

Subjects: Genetics and Genomics

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