Journal Article

Gearing up for genome-wide gene-association studies

Martin Farrall and Andrew P. Morris

in Human Molecular Genetics

Volume 14, issue suppl_2, pages R157-R162
Published in print October 2005 | ISSN: 0964-6906
Published online October 2005 | e-ISSN: 1460-2083 | DOI:
Gearing up for genome-wide gene-association studies

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One of the grand challenges of human genetics to systematically map by gene-association susceptibility genes for complex diseases is underway. High-throughput genotyping platforms have been developed; a comprehensive map of human genetic variation (HapMap) to guide efficient marker selection is imminent and many researchers have assembled suitable cohorts of patients. Expectations are understandably high and it is timely to review the promise and pitfalls of this strategy.

Journal Article.  5047 words. 

Subjects: Genetics and Genomics

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