Journal Article

The many facets of the Wilms' tumour gene, <i>WT1</i>

Peter Hohenstein and Nicholas D. Hastie

in Human Molecular Genetics

Volume 15, issue suppl_2, pages R196-R201
Published in print October 2006 | ISSN: 0964-6906
Published online October 2006 | e-ISSN: 1460-2083 | DOI: http://dx.doi.org/10.1093/hmg/ddl196
The many facets of the Wilms' tumour gene, WT1

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Over the years, many apparently contradictory findings and functions have been ascribed to the protein product of the WT1 tumour suppressor gene. These include being a transcriptional activator or repressor, a function in transcription versus RNA metabolism, and these days even a function as oncogene or tumour suppressor gene. To fully understand the role of WT1 in different diseases and normal development, we will need to understand these contradictions. In this review, we will discuss the present state of knowledge and suggest that a role for WT1 in influencing the mesenchymal–epithelial state of cells might be a common function that could explain many of the previously described findings.

Journal Article.  3829 words.  Illustrated.

Subjects: Genetics and Genomics

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