Journal Article

Systematic review and meta-analysis of the association between complementary factor H Y402H polymorphisms and age-related macular degeneration

Ammarin Thakkinstian, Pearline Han, Mark McEvoy, Wayne Smith, Josephine Hoh, Kristinn Magnusson, Kang Zhang and John Attia

in Human Molecular Genetics

Volume 15, issue 18, pages 2784-2790
Published in print September 2006 | ISSN: 0964-6906
Published online August 2006 | e-ISSN: 1460-2083 | DOI: http://dx.doi.org/10.1093/hmg/ddl220
Systematic review and meta-analysis of the association between complementary factor H Y402H polymorphisms and age-related macular degeneration

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Age-related macular degeneration (AMD) is the leading cause of blindness in the developed world and complement factor H (CFH) polymorphism has been found to associated with the AMD. We performed a meta-analysis to estimate the magnitude of the gene effect and the possible mode of action. A meta-analysis of eight studies assessing association between the CFH Y402H polymorphism and AMD was performed. Data extraction and study quality assessment were performed in duplicate, and heterogeneity and publication bias were explored. There was strong evidence for association between CFH and AMD, with those having CC and TC genotypes being roughly six and 2.5 times more likely to have AMD than patients with TT genotype, suggesting a co-dominant, multiplicative genetic model. The population attributable risk for the CC/TC genotype is 58.9%, i.e. the CFH polymorphism is involved in over half of all AMD. This meta-analysis summarizes the strong evidence for an association between CFH and AMD and indicates a multiplicative model with each C allele increasing the odds of AMD by ∼2.5-fold. This result is at least as important at the population level as ApoE4 and Alzheimer's disease, playing a role in almost 60% of AMD at the population level.

Journal Article.  3898 words.  Illustrated.

Subjects: Genetics and Genomics

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