Journal Article

A major susceptibility locus for HTLV-1 infection in childhood maps to chromosome 6q27

Sabine Plancoulaine, Antoine Gessain, Patricia Tortevoye, Anne Boland-Auge, Alexandre Vasilescu, Fumihiko Matsuda and Laurent Abel

in Human Molecular Genetics

Volume 15, issue 22, pages 3306-3312
Published in print November 2006 | ISSN: 0964-6906
Published online October 2006 | e-ISSN: 1460-2083 | DOI:
A major susceptibility locus for HTLV-1 infection in childhood maps to chromosome 6q27

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Human T-cell leukemia/lymphoma virus type 1 (HTLV-1) is a human oncoretrovirus causing adult T-cell leukemia/lymphoma and chronic neuromyelopathy. We previously showed by segregation analysis that a dominant gene controls HTLV-1 infection through breast-feeding in children of African origin. Here, we report the mapping of this locus by a genome-wide linkage analysis based on the genetic model provided by segregation analysis. Five pedigrees of African origin with HTLV-1 seropositive children were included in the study. Significant evidence for linkage (LOD score of 3.36, P=0.00004) was obtained for chomosomal region 6q27 when using the robust analysis including only HTLV-1-infected subjects. When HTLV-1 seronegative children born to infected mothers were added in the analysis, a maximum LOD score of 2.79 (P=0.0002) was obtained for chomosome 2p25. This result was mostly due to the largest pedigree of our sample, which alone gave a LOD score of 2.90 (P=0.00013). We further excluded the role of exonic variants of two candidate genes located in the linked regions, CCR6 (chemokine receptor 6) in 6q27 and ID2 (inhibitor of DNA binding 2) in 2p25. Our results, mapping a major susceptibility locus to chromosome 6q27 and suggesting genetic heterogeneity with another locus at 2p25, pave the way to the determination of the molecular basis of predisposition to HTLV-1 infection in children.

Journal Article.  4320 words.  Illustrated.

Subjects: Genetics and Genomics

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