Journal Article

Dangerous habits of a security guard: the two faces of p53 as a drug target

Andrei V. Gudkov and Elena A. Komarova

in Human Molecular Genetics

Volume 16, issue R1, pages R67-R72
Published in print April 2007 | ISSN: 0964-6906
Published online April 2007 | e-ISSN: 1460-2083 | DOI: http://dx.doi.org/10.1093/hmg/ddm052
Dangerous habits of a security guard: the two faces of p53 as a drug target

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Being most well-known tumor suppressor that is inactivated in tumors more frequently than any other gene, p53 has been recently recognized as a major player in a variety of pathologies caused by acute stresses of tissues that is responsible for massive cell loss from apoptosis. This created a controversial situation when effective treatment of acute pathology requires inhibition of a major cancer preventive factor that has been traditionally viewed as a target for therapeutic activation. Here we briefly review specific aspects of this problem and discuss the ways of its pharmacological resolution based on detailed knowledge of molecular mechanisms of p53 regulation and activity.

Journal Article.  4025 words.  Illustrated.

Subjects: Genetics and Genomics

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