Journal Article

Molecular basis of pluripotency

Lingyi Chen and George Q. Daley

in Human Molecular Genetics

Volume 17, issue R1, pages R23-R27
Published in print April 2008 | ISSN: 0964-6906
Published online April 2008 | e-ISSN: 1460-2083 | DOI:
Molecular basis of pluripotency

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Embryonic stem (ES) cells are pluripotent and capable of self-renewal, thus holding promise for regenerative medicine. Recent studies have begun to provide insights into the molecular mechanisms underlying pluripotency and self-renewal. In this article, we discuss the roles of transcriptional regulation, epigenetic regulation and miRNAs in the maintenance of pluripotency and the differentiation of ES cells.

Journal Article.  3217 words.  Illustrated.

Subjects: Genetics and Genomics

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