Journal Article

R125W coding variant in <i>TBC1D1</i> confers risk for familial obesity and contributes to linkage on chromosome 4p14 in the French population

David Meyre, Morgane Farge, Cécile Lecoeur, Christine Proenca, Emmanuelle Durand, Frédéric Allegaert, Jean Tichet, Michel Marre, Beverley Balkau, Jacques Weill, Jérôme Delplanque and Philippe Froguel

in Human Molecular Genetics

Volume 17, issue 12, pages 1798-1802
Published in print June 2008 | ISSN: 0964-6906
Published online March 2008 | e-ISSN: 1460-2083 | DOI: http://dx.doi.org/10.1093/hmg/ddn070
R125W coding variant in TBC1D1 confers risk for familial obesity and contributes to linkage on chromosome 4p14 in the French population

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Stone et al. previously reported an association between the TBC1D1 gene variant R125W (rs35859249) and severe obesity in women from US pedigrees. We attempted to replicate this result in 9714 French Caucasian individuals, combining family-based and general population studies. We confirmed an association with familial obesity (defined as body mass index (BMI) ≥ 97th percentile) in women from 1109 obesity-selected pedigrees (Z-score = 2.70, P = 0.008). Analysis of 16 microsatellite markers on chromosome 4 restricted to the 42 pedigrees carrying the TBC1D1 R125W variant allele also revealed a suggestive evidence of linkage with obesity (maximum likelihood binomial LOD of 2.73, P = 0.0002) on chromosome 4p14, where resides TBC1D1. In contrast, R125W variant was neither associated with BMI nor with obesity in a large population-based cohort. These results confirm a putative role of TBC1D1 R125W variant in familial obesity predisposition.

Journal Article.  3116 words.  Illustrated.

Subjects: Genetics and Genomics

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