Journal Article

Association study of the <i>NEDD9</i> gene with the risk of developing Alzheimer's and Parkinson's disease

Julien Chapuis, Frédéric Moisan, Georges Mellick, Alexis Elbaz, Peter Silburn, Florence Pasquier, Didier Hannequin, Corinne Lendon, Dominique Campion, Philippe Amouyel and Jean-Charles Lambert

in Human Molecular Genetics

Volume 17, issue 18, pages 2863-2867
Published in print September 2008 | ISSN: 0964-6906
Published online June 2008 | e-ISSN: 1460-2083 | DOI: http://dx.doi.org/10.1093/hmg/ddn183
Association study of the NEDD9 gene with the risk of developing Alzheimer's and Parkinson's disease

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Alzheimer's disease (AD) and Parkinson's disease (PD), the two most common neurodegenerative disorders in the elderly, have been hypothesized to share genetic determinants. Recently, Li et al. proposed that a variant in the NEDD9 gene may be one of these common genetic factors. We attempted to confirm this initial observation by conducting an equivalent analysis in terms of pathologies and sample size. We genotyped the NEDD9 rs760678 SNP in three independent AD case–control studies (n = 3176) and two independent PD case–control studies (n = 1855). However, we failed to detect an association of this SNP with the risk of developing AD or PD, in any of these populations. In conclusion, these data indicate that the rs760678 SNP of the NEDD9 gene is at best a weak genetic determinant of AD or PD.

Journal Article.  2527 words.  Illustrated.

Subjects: Genetics and Genomics

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