Journal Article

Depression Case Control (DeCC) Study fails to support involvement of the muscarinic acetylcholine receptor M2 (<i>CHRM2</i>) gene in recurrent major depressive disorder

Sarah Cohen-Woods, Daria Gaysina, Nick Craddock, Anne Farmer, Joanna Gray, Cerisse Gunasinghe, Farzana Hoda, Lisa Jones, Jo Knight, Ania Korszun, Michael J. Owen, Abram Sterne, Ian W. Craig and Peter McGuffin

in Human Molecular Genetics

Volume 18, issue 8, pages 1504-1509
Published in print April 2009 | ISSN: 0964-6906
Published online January 2009 | e-ISSN: 1460-2083 | DOI: http://dx.doi.org/10.1093/hmg/ddp051
Depression Case Control (DeCC) Study fails to support involvement of the muscarinic acetylcholine receptor M2 (CHRM2) gene in recurrent major depressive disorder

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It has been suggested that alteration in the muscarinic-cholinergic system is involved in modulation of mood. Three studies have reported linkage on chromosome 7 with major depressive disorder (MDD) in or close to a region containing the muscarinic receptor CHRM2 gene. A haplotype of SNPs located in CHRM2 (rs1824024–rs2061174–rs324650) has been significantly associated with MDD in a previous study. We report the first study investigating this gene in a large, adequately powered, clinical depression case–control sample (n = 1420 cases, 1624 controls). Our data fail to support association with the CHRM2 polymorphisms previously implicated in the genetic aetiology of depression. It is possible our failure to replicate may be a consequence of differences in definition of the MDD phenotype and/or ethnic differences.

Journal Article.  3617 words. 

Subjects: Genetics and Genomics

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