Journal Article

Positive selection of a <i>CD36</i> nonsense variant in sub-Saharan Africa, but no association with severe malaria phenotypes

Andrew E. Fry, Anita Ghansa, Kerrin S. Small, Alejandro Palma, Sarah Auburn, Mahamadou Diakite, Angela Green, Susana Campino, Yik Y. Teo, Taane G. Clark, Anna E. Jeffreys, Jonathan Wilson, Muminatou Jallow, Fatou Sisay-Joof, Margaret Pinder, Michael J. Griffiths, Norbert Peshu, Thomas N. Williams, Charles R. Newton, Kevin Marsh, Malcolm E. Molyneux, Terrie E. Taylor, Kwadwo A. Koram, Abraham R. Oduro, William O. Rogers, Kirk A. Rockett, Pardis C. Sabeti and Dominic P. Kwiatkowski

in Human Molecular Genetics

Volume 18, issue 14, pages 2683-2692
Published in print July 2009 | ISSN: 0964-6906
Published online April 2009 | e-ISSN: 1460-2083 | DOI: http://dx.doi.org/10.1093/hmg/ddp192
Positive selection of a CD36 nonsense variant in sub-Saharan Africa, but no association with severe malaria phenotypes

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The prevalence of CD36 deficiency in East Asian and African populations suggests that the causal variants are under selection by severe malaria. Previous analysis of data from the International HapMap Project indicated that a CD36 haplotype bearing a nonsense mutation (T1264G; rs3211938) had undergone recent positive selection in the Yoruba of Nigeria. To investigate the global distribution of this putative selection event, we genotyped T1264G in 3420 individuals from 66 populations. We confirmed the high frequency of 1264G in the Yoruba (26%). However, the 1264G allele is less common in other African populations and absent from all non-African populations without recent African admixture. Using long-range linkage disequilibrium, we studied two West African groups in depth. Evidence for recent positive selection at the locus was demonstrable in the Yoruba, although not in Gambians. We screened 70 variants from across CD36 for an association with severe malaria phenotypes, employing a case–control study of 1350 subjects and a family study of 1288 parent–offspring trios. No marker was significantly associated with severe malaria. We focused on T1264G, genotyping 10 922 samples from four African populations. The nonsense allele was not associated with severe malaria (pooled allelic odds ratio 1.0; 95% confidence interval 0.89–1.12; P = 0.98). These results suggest a range of possible explanations including the existence of alternative selection pressures on CD36, co-evolution between host and parasite or confounding caused by allelic heterogeneity of CD36 deficiency.

Journal Article.  6180 words.  Illustrated.

Subjects: Genetics and Genomics

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