Journal Article

<i>Prdm16</i> is required for normal palatogenesis in mice

Bryan C. Bjork, Annick Turbe-Doan, Mary Prysak, Bruce J. Herron and David R. Beier

in Human Molecular Genetics

Volume 19, issue 5, pages 774-789
Published in print March 2010 | ISSN: 0964-6906
Published online December 2009 | e-ISSN: 1460-2083 | DOI: http://dx.doi.org/10.1093/hmg/ddp543
Prdm16 is required for normal palatogenesis in mice

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Transcriptional cofactors are essential to the regulation of transforming growth factor β (TGFβ) superfamily signaling and play critical and widespread roles during embryonic development, including craniofacial development. We describe the cleft secondary palate 1 (csp1) N-ethyl-N-nitrosourea-induced mouse model of non-syndromic cleft palate (NSCP) that is caused by an intronic Prdm16 splicing mutation. Prdm16 encodes a transcriptional cofactor that regulates TGFβ signaling, and its expression pattern is consistent with a role in palate and craniofacial development. The cleft palate (CP) appears to be the result of micrognathia and failed palate shelf elevation due to physical obstruction by the tongue, resembling human Pierre Robin sequence (PRS)-like cleft secondary palate. PRDM16 should be considered a candidate for mutation in human clefting disorders, especially NSCP and PRS-like CP.

Journal Article.  9244 words.  Illustrated.

Subjects: Genetics and Genomics

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