Journal Article

Elevated expression of MeCP2 in cardiac and skeletal tissues is detrimental for normal development

Matías Alvarez-Saavedra, Loreto Carrasco, Sylvia Sura-Trueba, Vera Demarchi Aiello, Katherina Walz, José Xavier Neto and Juan I. Young

in Human Molecular Genetics

Volume 19, issue 11, pages 2177-2190
Published in print June 2010 | ISSN: 0964-6906
Published online March 2010 | e-ISSN: 1460-2083 | DOI: http://dx.doi.org/10.1093/hmg/ddq096
Elevated expression of MeCP2 in cardiac and skeletal tissues is detrimental for normal development

Show Summary Details

Preview

MeCP2 plays a critical role in interpreting epigenetic signatures that command chromatin conformation and regulation of gene transcription. In spite of MeCP2's ubiquitous expression, its functions have always been considered in the context of brain physiology. In this study, we demonstrate that alterations of the normal pattern of expression of MeCP2 in cardiac and skeletal tissues are detrimental for normal development. Overexpression of MeCP2 in the mouse heart leads to embryonic lethality with cardiac septum hypertrophy and dysregulated expression of MeCP2 in skeletal tissue produces severe malformations. We further show that MeCP2's expression in the heart is developmentally regulated; further suggesting that it plays a key role in regulating transcriptional programs in non-neural tissues.

Journal Article.  8226 words.  Illustrated.

Subjects: Genetics and Genomics

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.