Journal Article

Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes

Lu Qi, Marilyn C. Cornelis, Peter Kraft, Kristopher J. Stanya, W.H. Linda Kao, James S. Pankow, Josée Dupuis, Jose C. Florez, Caroline S. Fox, Guillaume Paré, Qi Sun, Cynthia J. Girman, Cathy C. Laurie, Daniel B. Mirel, Teri A. Manolio, Daniel I. Chasman, Eric Boerwinkle, Paul M. Ridker, David J. Hunter, James B. Meigs, Chih-Hao Lee, Rob M. van Dam and Frank B. Hu

in Human Molecular Genetics

Volume 19, issue 13, pages 2706-2715
Published in print July 2010 | ISSN: 0964-6906
Published online April 2010 | e-ISSN: 1460-2083 | DOI: http://dx.doi.org/10.1093/hmg/ddq156
Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes

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To identify type 2 diabetes (T2D) susceptibility loci, we conducted genome-wide association (GWA) scans in nested case–control samples from two prospective cohort studies, including 2591 patients and 3052 controls of European ancestry. Validation was performed in 11 independent GWA studies of 10 870 cases and 73 735 controls. We identified significantly associated variants near RBMS1 and ITGB6 genes at 2q24, best-represented by SNP rs7593730 (combined OR = 0.90, 95% CI = 0.86–0.93; P = 3.7 × 10−8). The frequency of the risk-lowering allele T is 0.23. Variants in this region were nominally related to lower fasting glucose and HOMA-IR in the MAGIC consortium (P < 0.05). These data suggest that the 2q24 locus may influence the T2D risk by affecting glucose metabolism and insulin resistance.

Journal Article.  5448 words.  Illustrated.

Subjects: Genetics and Genomics

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