Journal Article

The human metagenome: our other genome?

Thomas Brüls and Jean Weissenbach

in Human Molecular Genetics

Volume 20, issue R2, pages R142-R148
Published in print October 2011 | ISSN: 0964-6906
Published online August 2011 | e-ISSN: 1460-2083 | DOI:
The human metagenome: our other genome?

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For about a decade, the human microbiota has been investigated using molecular procedures that are now systematized via metagenomics. Several large scale studies are underway with the goal of establishing a set of reference data, such as catalogues of genes, microbial species and complete genome sequences of strains colonizing the various body sites. A first series of conclusions can be drawn from this ‘natural history’ approach that will also lay the ground for further studies aiming at understanding—in an ecological perspective—the mechanisms ensuring stable operation of the microbiota in healthy individuals, and how changes in its composition (dysbiosis) may result in diseases.

Journal Article.  4338 words.  Illustrated.

Subjects: Genetics and Genomics

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