Journal Article

Replication of loci influencing ages at menarche and menopause in Hispanic women: the Women's Health Initiative SHARe Study

Christina T. L. Chen, Lindsay Fernández-Rhodes, Robert G. Brzyski, Christopher S. Carlson, Zhao Chen, Gerardo Heiss, Kari E. North, Nancy F. Woods, Aleksandar Rajkovic, Charles Kooperberg and Nora Franceschini

in Human Molecular Genetics

Volume 21, issue 6, pages 1419-1432
Published in print March 2012 | ISSN: 0964-6906
Published online November 2011 | e-ISSN: 1460-2083 | DOI: http://dx.doi.org/10.1093/hmg/ddr570
Replication of loci influencing ages at menarche and menopause in Hispanic women: the Women's Health Initiative SHARe Study

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Several genome-wide studies have identified loci associated with reproductive traits, such as ages of menarche and menopause, in women of European ancestry. In this study, we investigated the relevance of these loci in minority US Hispanic women. We utilized data from 3468 women who were genotyped as a part of the Women's Health Initiative SNP Health Association Resource. We replicated associations of eight loci (LRP18, LIN28B, CENPW, INHBA, TMEM38B, ZNF483, NFAT5 and OLFM2) with age at menarche, and of two loci (MCM8 and BRSK1/TMEM150B) with age at menopause. The MCM8 locus was also associated with early menopause risk. Three loci (CENPW, MCM8 and BRSK1/TMEM150B) were associated with the length of reproductive lifespan. We provide evidence that genetic variants influencing reproductive traits identified in European populations are also important in minority US Hispanic women.

Journal Article.  9338 words.  Illustrated.

Subjects: Genetics and Genomics

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