Journal Article

Mannan-binding lectin concentration during normal human pregnancy

David C. Kilpatrick

in Human Reproduction

Published on behalf of European Society of Human Reproduction and Embryology

Volume 15, issue 4, pages 941-943
Published in print April 2000 | ISSN: 0268-1161
Published online April 2000 | e-ISSN: 1460-2350 | DOI: http://dx.doi.org/10.1093/humrep/15.4.941
Mannan-binding lectin concentration during normal human pregnancy

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Relative deficiency of mannan-binding lectin (MBL) is associated with recurrent miscarriage. To investigate whether MBL concentration alters as a result of pregnancy, serial measurements were made in 14 patients before and during normal early pregnancy. Additionally, a longitudinal study was made of one individual over several years and including two normal pregnancies. Three (20%) subjects experienced a significant increase in MBL concentration during pregnancy. It was concluded that a modest but significant increase in MBL concentration can result from pregnancy, but it is a rare occurrence in the first trimester.

Keywords: mannan-binding lectin; recurrent miscarriage; recurrent spontaneous abortion

Journal Article.  2235 words.  Illustrated.

Subjects: Reproductive Medicine

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