Journal Article

Acquired haemophilia due to factor VIII inhibitors in ovarian hyperstimulation syndrome: Case report

Tomoko Nakauchi‐Tanaka, Satoshi Sohda, Katsumi Someya, Keiko Kono, Hiromi Hamada and Hiroyuki Yoshikawa

in Human Reproduction

Published on behalf of European Society of Human Reproduction and Embryology

Volume 18, issue 3, pages 506-508
Published in print March 2003 | ISSN: 0268-1161
Published online March 2003 | e-ISSN: 1460-2350 | DOI: http://dx.doi.org/10.1093/humrep/deg112
Acquired haemophilia due to factor VIII inhibitors in ovarian hyperstimulation syndrome: Case report

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A 31‐year‐old nulligravida woman developed an acquired factor VIII inhibitor associated with severe ovarian hyperstimulation syndrome (OHSS). She developed haematouria, ecchymosis, and intramuscular bleeding following the severe OHSS. Laboratory examinations showed a markedly prolonged activated partial thromboplastin time and a low level of factor VIII activity. Treatment with prothrombin complex concentrate and factor VIII inhibitor bypassing agent was successful in reducing the inhibitor so that she delivered a healthy baby via spontaneous vaginal delivery. Acquired haemophilia is a life‐threatening disorder. This is the first case report of acquired haemophilia in OHSS.

Keywords: Key words: acquired haemophilia/assisted conception/factor VIII inhibitor/OHSS

Journal Article.  1776 words. 

Subjects: Reproductive Medicine

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