Journal Article

Value of the sperm chromatin dispersion test in predicting pregnancy outcome in intrauterine insemination: a blind prospective study*

Lourdes Muriel, Marcos Meseguer, Jose Luis Fernández, Juan Alvarez, José Remohí, Antonio Pellicer and Nicolás Garrido

in Human Reproduction

Published on behalf of European Society of Human Reproduction and Embryology

Volume 21, issue 3, pages 738-744
Published in print March 2006 | ISSN: 0268-1161
Published online November 2005 | e-ISSN: 1460-2350 | DOI: http://dx.doi.org/10.1093/humrep/dei403
Value of the sperm chromatin dispersion test in predicting pregnancy outcome in intrauterine insemination: a blind prospective study*

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BACKGROUND: Sperm DNA integrity has been used as a new marker of sperm quality in the prediction of pregnancy. Nevertheless, no previous study has been performed by analysing the same samples that were employed in assisted reproduction. The main objective of this work was to correlate sperm chromatin dispersion (SCD), measured by the SCD test, with semen parameters and pregnancy outcome in intrauterine insemination (IUI). METHODS: A total of 100 semen samples obtained from males of couples undergoing IUI were analysed by the SCD test before and after swim-up, and the results were correlated with semen parameters and pregnancy outcome. RESULTS: SCD was negatively correlated with sperm motility in both ejaculated and processed semen. Sperm recovered by swim-up did not show a significant improvement in DNA integrity. No correlation was found between SCD and pregnancy outcome in IUI. CONCLUSIONS: DNA dispersion, as measured by the SCD test, is not correlated with pregnancy outcome in IUI.

Keywords: DNA; intrauterine insemination; sperm; sperm chromatin dispersion test

Journal Article.  5509 words.  Illustrated.

Subjects: Reproductive Medicine

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