Journal Article

Modelling the macrophage invasion of tumours: Effects on growth and composition

MARKUS R. OWEN and JONATHAN A. SHERRATT

in Mathematical Medicine and Biology: A Journal of the IMA

Published on behalf of Institute of Mathematics and its Applications

Volume 15, issue 2, pages 165-185
Published in print June 1998 | ISSN: 1477-8599
Published online June 1998 | e-ISSN: 1477-8602 | DOI: http://dx.doi.org/10.1093/imammb/15.2.165
Modelling the macrophage invasion of tumours: Effects on growth and composition

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Even in the early stages of their development, tumours are not simply a homogeneous grouping of mutant cells; rather, they develop in tandem with normal tissue cells, and also recruit other cell types including lymphatic cells and the endothelial cells required for the development of a blood supply. It has been repeatedly seen that macrophages form a significant proportion of the tumour mass, and that they can have a variety of effects upon the tumour, leading to a delicate balance between growth promotion and inhibition. This paper develops a model for the early, avascular growth of a tumour, concentrating on the inhibitory effect of macrophages due to their cytolytic activity. It is shown that such an immune response is not sufficient to prevent growth, due to it being a second-order process with respect to the density of the tumour cells present However, the presence of macrophages does have important effects on the tumour composition, and the authors perform a detailed bifurcation analysis of their model to clarify this. An extended model is also considered which incorporates addition of exogenous chemical regulators. In this case, the model admits the possibility of tumour regression, and the therapeutic implications of this are discussed.

Keywords: cancer; cytolysis; immunotherapy; macrophage; tumour composition

Journal Article.  0 words. 

Subjects: Applied Mathematics ; Biomathematics and Statistics

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