Journal Article

Idiopathic intracranial hypertension and transverse sinus stenosis: a modelling study

Scott A. Stevens, Michelle Previte, William D. Lakin, Nimish J.Thakore, Paul L. Penar and Brandon Hamschin

in Mathematical Medicine and Biology: A Journal of the IMA

Published on behalf of Institute of Mathematics and its Applications

Volume 24, issue 1, pages 85-109
Published in print March 2007 | ISSN: 1477-8599
Published online March 2007 | e-ISSN: 1477-8602 | DOI: http://dx.doi.org/10.1093/imammb/dql025
Idiopathic intracranial hypertension and transverse sinus stenosis: a modelling study

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Idiopathic intracranial hypertension (IIH) is a syndrome of unknown etiology characterized by elevated intracranial pressure (ICP). Although a stenosis of the transverse sinus has been observed in many IIH patients, the role this feature plays in IIH is in dispute. In this paper, a lumped-parameter model is developed for the purpose of analytically investigating the elevated pressures associated with IIH and a collapsible transverse sinus. This analysis yields practical predictions regarding the degree of elevated ICPs and the effectiveness of various treatment methods. Results suggest that IIH may be caused by a sufficiently collapsible transverse sinus, but it is also possible that a stenosed sinus may persist following resolution of significant intracranial hypertension.

Keywords: lumped-parameter model; intracranial pressure; idiopathic intracranial hypertension; cerebrospinal fluid; venous sinus.

Journal Article.  0 words. 

Subjects: Applied Mathematics ; Biomathematics and Statistics

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