Journal Article

An enzyme kinetic model of blood island formation

Andrew Matteson

in Mathematical Medicine and Biology: A Journal of the IMA

Published on behalf of Institute of Mathematics and its Applications

Volume 25, issue 3, pages 233-245
Published in print September 2008 | ISSN: 1477-8599
Published online August 2008 | e-ISSN: 1477-8602 | DOI: http://dx.doi.org/10.1093/imammb/dqn016
An enzyme kinetic model of blood island formation

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Blood islands are conglomerations of prevascular stem cells that form during vasculogenesis, a function critical to early vascular and hematopoietic development. In this paper, a model of blood island formation is proposed employing the approach of classical enzyme kinetics. Deterministic simulations of the model show the formation of blood island-like structures. These are compared to murine blood islands.

Keywords: Blood islands; GATA-2; reaction-diffusion equations; hematopoiesis; vasculogenesis

Journal Article.  0 words. 

Subjects: Applied Mathematics ; Biomathematics and Statistics

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