Journal Article

Analytic solution during an infusion test of the linear unsteady poroelastic equations in a spherically symmetric model of the brain

Benedikt Wirth and Ian Sobey

in Mathematical Medicine and Biology: A Journal of the IMA

Published on behalf of Institute of Mathematics and its Applications

Volume 26, issue 1, pages 25-61
Published in print March 2009 | ISSN: 1477-8599
Published online December 2008 | e-ISSN: 1477-8602 | DOI: http://dx.doi.org/10.1093/imammb/dqn021
Analytic solution during an infusion test of the linear unsteady poroelastic equations in a spherically symmetric model of the brain

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This work determines the spatial and temporal distribution of cerebrospinal fluid (CSF) pressure and brain displacement during an infusion test in a spherically symmetric model of the brain. The response of CSF pressure and parenchymal displacement to blood pressure pulsations is determined in the solution. We use a spherically symmetric, three-component poroelastic model of the brain, differentiating between the solid elastic matrix, the CSF and the arterial blood compartments. The governing equations are linearized with quasi-constant poroelastic parameters. The solution does reproduce the average intracranial pressure increase during the test as well as the rise in CSF pressure pulsation amplitude due to transmission of blood pressure oscillations. In addition, the CSF flux into and out of the parenchyma is shown over time.

Keywords: multi-poroelasticity; cerebrospinal fluid; infusion test; pressure oscillations; analytic solution

Journal Article.  0 words. 

Subjects: Applied Mathematics ; Biomathematics and Statistics

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