Journal Article

Computational models of VEGF-associated angiogenic processes in cancer

Marianne O. Stefanini, Amina A. Qutub, Feilim Mac Gabhann and Aleksander S. Popel

in Mathematical Medicine and Biology: A Journal of the IMA

Published on behalf of Institute of Mathematics and its Applications

Volume 29, issue 1, pages 85-94
Published in print March 2012 | ISSN: 1477-8599
Published online January 2011 | e-ISSN: 1477-8602 | DOI: http://dx.doi.org/10.1093/imammb/dqq025
Computational models of VEGF-associated angiogenic processes in cancer

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Tumour angiogenesis allows a growing mass of cancer cells to overcome oxygen diffusion limitation and to increase cell survival. The growth of capillaries from pre-existing blood vessels is the result of numerous signalling cascades involving different molecules and of cellular events involving multiple cell and tissue types. Computational models offer insight into the mechanisms governing angiogenesis and provide quantitative information on parameters difficult to assess by experiments alone. In this article, we summarize results from computational models of tumour angiogenic processes with a focus on the molecular-detailed vascular endothelial growth factor-associated models that have been developed in our laboratory, spanning multiple scales from the molecular to whole body.

Keywords: computational biology; systems biology; angiogenesis

Journal Article.  0 words. 

Subjects: Applied Mathematics ; Biomathematics and Statistics

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