Journal Article

Sequence Variation of Latent Membrane Protein-1 of Epstein-Barr Virus Strains Associated with Hairy Leukoplakia

Joel M. Palefsky, Jennifer Berline, Maria-Elena Penaranda, Evelyne T. Lennette, Deborah Greenspan and John S. Greenspan

in The Journal of Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 173, issue 3, pages 710-713
Published in print March 1996 | ISSN: 0022-1899
Published online March 1996 | e-ISSN: 1537-6613 | DOI: http://dx.doi.org/10.1093/infdis/173.3.710
Sequence Variation of Latent Membrane Protein-1 of Epstein-Barr Virus Strains Associated with Hairy Leukoplakia

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The Epstein-Barr virus (EBV)latent membrane protein (LMP)-1 is expressed in hairy leukoplakia (HL), but data on LMP-1 sequence variation of HL isolates are limited. Variation in the LMP-1 repeat region and presence of a 30-nt deletion were studied using DNA scrapings from 28 HL lesions. cDNAs from 3 different HL isolates were sequenced, 2 from lymphocyte cell lines (LCLs) generated using HL biopsy material. The deletion was found in 16 (57%) of 28 HL scrapings, and multiple repeat region variants were seen in 13 scrapings (46%). HL LMP sequences were similar to those described in nasopharyngeal cancer and lymphoma tissues, including two motifs of four amino acid changes relative to B95-8 upstream and downstream of the repeat region, respectively. Generation of LCLs using HL biopsy material confirmed the ability of HL EBV strains to infect and transform lymphocytes.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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