Journal Article

Streptococcal Pyrogenic Exotoxin A Release, Distribution, and Role in a Murine Model of Fasciitis and Multiorgan Failure Due to <i>Streptococcus pyogenes</i>

Shiranee Sriskandan, David Moyes, Lee K. Buttery, Thomas Krausz, Thomas J. Evans, Julia Polak and Jonathan Cohen

in The Journal of Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 173, issue 6, pages 1399-1407
Published in print June 1996 | ISSN: 0022-1899
Published online June 1996 | e-ISSN: 1537-6613 | DOI: http://dx.doi.org/10.1093/infdis/173.6.1399
Streptococcal Pyrogenic Exotoxin A Release, Distribution, and Role in a Murine Model of Fasciitis and Multiorgan Failure Due to Streptococcus pyogenes

More Like This

Show all results sharing these subjects:

  • Infectious Diseases
  • Immunology
  • Public Health and Epidemiology
  • Microbiology

GO

Show Summary Details

Preview

The role of streptococcal pyrogenic exotoxin A (SPEA) was evaluated in a murine model of fasciitis and multiorgan failure due to a toxigenic strain of Streptococcus pyogenes. Increased serum levels of SPEA at 15 and 21 h were associated with a survival time of <24 h. Levels of SPEA correlated with interleukin-6 levels. Immunostaining showed SPEA localized to renal and hepatic cells. Neutralizing rabbit antibody to SPEA was administered to mice challenged with-S. Pyogenes, but no effect on survival was observed. Vaccination of mice with recombinant SPEA enhanced mortality due to streptococcal infection, despite the development of neutralizing immunity to the toxin prior to infection. Hence, SPEA is produced systemically during S. Pyogenes soft-tissue infection, and increased levels are associated with reduced survival. In this model, however, SPEA did not appear to playa dominant role in pathogenesis; passive immunization against SPEA was not protective, and active immunization enhanced mortality.

Journal Article.  0 words. 

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.