Journal Article

Comparison of the Antimicrobial Activity of Deactivated Human Macrophages Challenged with <i>Aspergillus fumigatus</i> and <i>Listeria monocytogenes</i>

Ivetta Meier-Osusky, Gabriele Schoedon, Franziska Bläuer, Markus Schneemann and Andreas Schaffner

in The Journal of Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 174, issue 3, pages 651-654
Published in print September 1996 | ISSN: 0022-1899
Published online September 1996 | e-ISSN: 1537-6613 | DOI: http://dx.doi.org/10.1093/infdis/174.3.651
Comparison of the Antimicrobial Activity of Deactivated Human Macrophages Challenged with Aspergillus fumigatus and Listeria monocytogenes

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The anticonidial activity of human monocytes deactivated by cytokines interleukin (IL)-4 and IL-10 and the hormone dexamethasone was studied and compared with antilisterial activity. Dexamethasone had the largest effect on the anticonidial activity and suppressed germination-inhibiting activity and elimination of ingested spores by macrophages more than the cytokines did. Maximally active concentrations of IL-10 had a similar but significantly smaller deactivating effect. IL-4, in contrast to IL-10 and dexamethasone, did not reduce anticonidial activity. However, IL-4 and IL-10 were equally potent in deactivating human macrophages against Listeria monocytogenes, whereas dexamethasone was significantly less potent in the Listeria model. These observations indicate that all three mediators lessen antimicrobial activity but that this effect depends on the test organism studied and is apparently mediated through regulation of different antimicrobial systems operating against a particular microorganism.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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