Journal Article

Distribution of Infecting Hepatitis C Virus Genotypes in End-Stage Liver Disease Patients at a Large American Transplantation Center

Hugo E. Vargas, Lian-Fu Wang, Tomasz Laskus, Anthony Poutous, Randall Lee, Anthony Demetris, Forrest Dodson, Adrian Casavilla, John Fung, Timothy Gayowski, Nina Singh, Ignazio Marino and Jorge Rakela

in The Journal of Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 175, issue 2, pages 448-450
Published in print February 1997 | ISSN: 0022-1899
Published online February 1997 | e-ISSN: 1537-6613 | DOI: http://dx.doi.org/10.1093/infdis/175.2.448
Distribution of Infecting Hepatitis C Virus Genotypes in End-Stage Liver Disease Patients at a Large American Transplantation Center

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The distribution of hepatitis C virus (HCV) genotypes was studied in 202 anti-HCV-positive liver transplant candidates with end-stage liver disease. HCV sequences were successfully amplified from 185 patients: In the first 100, the genotype was determined by direct sequencing in the NS5 region, and in the remaining 85, type-specific primers were used for genotyping. Eighty-five patients (46.0%) were infected with type 1a HCV strains, 52 (28.1%) with type 1b, 14 (7.6%) with type 2b, 13 (7.0%) with type 4, 5 (2.7%) with type 3a, 2 (1.1%) with type 2a, and 1 (0.5%) with type 2c. Thirteen HCV-positive patients (7.0%) could not be genotyped. The relatively low prevalence of genotype lb in this population of end-stage liver disease patients speaks against postulated higher pathogenicity of this genotype.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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