Journal Article

Effects of Blood Group Antigen–Binding Adhesin Expression during <i>Helicobacter pylori</i> Infection of Mongolian Gerbils

Tomoyuki Ohno, Anna Vallström, Massimo Rugge, Hiroyoshi Ota, David Y. Graham, Anna Arnqvist and Yoshio Yamaoka

in The Journal of Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 203, issue 5, pages 726-735
Published in print March 2011 | ISSN: 0022-1899
Published online January 2011 | e-ISSN: 1537-6613 | DOI: http://dx.doi.org/10.1093/infdis/jiq090
Effects of Blood Group Antigen–Binding Adhesin Expression during Helicobacter pylori Infection of Mongolian Gerbils

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Helicobacter pylori outer membrane proteins, such as the blood group antigen–binding adhesin (BabA), are associated with severe pathological outcomes. However, the in vivo role of BabA during long-term infection is not clear. In this study, Mongolian gerbils were infected with H. pylori and necropsied continuously during 18 months. Bacterial clones were recovered and analyzed for BabA expression, Leb-binding activity, and adhesion to gastric mucosa. BabA expression was completely absent by 6 months post-infection. Loss of BabA expression was attributable to nucleotide changes within the babA gene that resulted in a truncated BabA. In response to the infection, changes in the epithelial glycosylation pattern were observed that were similar to responses observed in humans and monkeys. Furthermore, infections with BabA-expressing and BabA-nonexpressing H. pylori showed no differences in colonization, but infection with the BabA-expressing strain exhibited histological changes and increased inflammatory cell infiltration. This suggests that BabA expression contributes to severe mucosal injury.

Journal Article.  4869 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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