Journal Article

Serotype-Specific Cell-Mediated Immunity Associated With Clearance of Homotypic Group B <i>Streptococcus</i> Rectovaginal Colonization in Pregnant Women

Gaurav Kwatra, Peter V. Adrian, Tinevimbo Shiri, Alane Izu, Clare L. Cutland, Eckhart J. Buchmann and Shabir A. Madhi

in The Journal of Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 213, issue 12, pages 1923-1926
Published in print June 2016 | ISSN: 0022-1899
Published online March 2016 | e-ISSN: 1537-6613 | DOI: http://dx.doi.org/10.1093/infdis/jiw056
Serotype-Specific Cell-Mediated Immunity Associated With Clearance of Homotypic Group B Streptococcus Rectovaginal Colonization in Pregnant Women

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We investigated the association between group B Streptococcus (GBS) serotype-specific capsular polysaccharide cellular immunity, measured with enzyme-linked immunospot (ELISPOT) interferon γ release assay at 20 weeks gestation in pregnant women, and its effect on rectovaginal serotype-specific GBS colonization up to 37 weeks gestation. Among women colonized by serotype III at enrollment, interferon γ ELISPOT positivity was more common in those in whom colonization was cleared (44.4%) than in those in whom colonization persisted (7.4%; P = .008), with a similar trend observed for serotype Ia. Presence of serotype-specific capsular polysaccharide cell-mediated immunity contributes to the clearance of GBS rectovaginal colonization.

Keywords: group B Streptococcus; cellular immunity; colonization

Journal Article.  2909 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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