Journal Article

Genetic Evolution of a <i>Helicobacter pylori</i> Acid-Sensing Histidine Kinase and Gastric Disease

Uma Krishna, Judith Romero-Gallo, Giovanni Suarez, Ayeetin Azah, Andrzej M. Krezel, Matthew G. Varga, Mark H. Forsyth and Richard M. Peek

in The Journal of Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 214, issue 4, pages 644-648
Published in print August 2016 | ISSN: 0022-1899
Published online May 2016 | e-ISSN: 1537-6613 | DOI: http://dx.doi.org/10.1093/infdis/jiw189
Genetic Evolution of a Helicobacter pylori Acid-Sensing Histidine Kinase and Gastric Disease

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Helicobacter pylori is the strongest risk factor for gastric adenocarcinoma, which develops within a hypochlorhydric environment. We sequentially isolated H. pylori (strain J99) from a patient who developed corpus-predominant gastritis and hypochlorhydia over a 6-year interval. Archival J99 survived significantly better under acidic conditions than recent J99 strains. H. pylori arsRS encodes a 2-component system critical for stress responses; recent J99 isolates harbored 2 nonsynonymous arsS mutations, and arsS inactivation abolished acid survival. In vivo, acid-resistant archival, but not recent J99, successfully colonized high-acid-secreting rodents. Thus, genetic evolution of arsS may influence progression to hypochlorhydia and gastric cancer.

Keywords: H. pylori; hypochlorhydia; acid resistance

Journal Article.  3065 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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