Journal Article

The appearance of Thy-1<sup>−</sup> donor T cells in the peripheral circulation 3–6 weeks after bone marrow transplantation suggests an extrathymic origin

Rui-kun Zhong, Albert D. Donnenberg, Linette Edison and David E. Harrison

in International Immunology

Published on behalf of Japanese Society for Immunology

Volume 8, issue 2, pages 171-176
Published in print February 1996 | ISSN: 0953-8178
e-ISSN: 1460-2377 | DOI: https://dx.doi.org/10.1093/intimm/8.2.171
The appearance of Thy-1− donor T cells in the peripheral circulation 3–6 weeks after bone marrow transplantation suggests an extrathymic origin

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Donor and host T cells were distinguished by T cell antigen marker Thy-1 isotype and cytoplasmic isozyme Gpi-1 in thisstudy of bone marrow transplantation between congenic mice. During the first 3–6 weeks after irradiation and marrowtransfer, percentages of cells bearing the donor Thy-1 isotype in the periphery are much lower than percentages of T cells bearing the donor Gpi-1 marker. Apparently a population of Thy-1 donor T cells exists for several weeks after bone marrow transplantation. Further study showed that this population of CD3+, Thy-1 donor T cells expressed CD4+ or CD8+ and was found in peripheral blood and spleen but not in the thymus. This finding suggests their extrathymic origin.

Keywords: B6-TC triple congenic mouse; CD3; CD4; CD8; Gpi-1

Journal Article.  0 words. 

Subjects: Immunology ; Biological Sciences

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