Journal Article

Centrocytes rapidly adopt a memory B cell phenotype on co-culture with autologous germinal centre T cell-enriched preparations

Montserrat Casamayor-Palleja, Jean Feuillard, Jennifer Ball, Marion Drew and Ian C. M. MacLennan

in International Immunology

Published on behalf of Japanese Society for Immunology

Volume 8, issue 5, pages 737-744
Published in print May 1996 | ISSN: 0953-8178
e-ISSN: 1460-2377 | DOI: http://dx.doi.org/10.1093/intimm/8.5.737
Centrocytes rapidly adopt a memory B cell phenotype on co-culture with autologous germinal centre T cell-enriched preparations

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B cells, after mutating their Ig V-region genes in germinal centres (GC), undergo apoptosis, unless they receive antigen-dependent selection signals. The signals appear to be delivered by GC T cells, require CD40 ligand expression and may induce differentiation to memory cells. Cultured GC B cells are prevented from entering apoptosis by ligating their surface CD40, but the resulting phenotype is not that associated with B cells found in vivo. Conversely, GC B cells rapidly adopt a memory B cell phenotype on culture with autologous memory CD4+ T cells that have been induced to express CD40 ligand transiently. This effect is prevented by blocking CD4+ ligand. Naive CD4+ T cells, induced to express CD40 ligand, do not prevent GC B cells undergoing apoptosis.

Keywords: centrocyte; germinal centre T cell; memory B cell

Journal Article.  0 words. 

Subjects: Immunology ; Biological Sciences

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