Journal Article

Demonstration of a cross-talk between IL-2 and IL-5 in Phosphorylation of IL-2 and IL-5 receptor β chains

Kazuyuki Ohbo, Hironobu Asoa, Taku Kouro, Masataka Nakamura, Satoshi Takaki, Yuji Kikuchi, Katsuiku Hirokawa, Akira Tominaga, Kiyoshi Takatsu and Kazuo Sugamura

in International Immunology

Published on behalf of Japanese Society for Immunology

Volume 8, issue 6, pages 951-960
Published in print June 1996 | ISSN: 0953-8178
e-ISSN: 1460-2377 | DOI: http://dx.doi.org/10.1093/intimm/8.6.951
Demonstration of a cross-talk between IL-2 and IL-5 in Phosphorylation of IL-2 and IL-5 receptor β chains

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Malaria infection induces the production of serum antibodies to a variety of malaria antigens but the prevalence of antibodies to any particular antigen ins typically mucb less than 100%. It has been assumed that non-responsiveness to defined antigens in malaria immune subjects is due to HLA mediated restricution of the Immune response. In this study we have investigated the role of HLA and non-HLA genes in the antibody response to two merozoite surface antigens (MSP1 and MSP2) and a sexual stage antigen (Pfs260/230) opf P{lasmodium falcpartum, and conclude that host genotype is not a major determinant of responsiveness. Although antibody levels vary in accordance with seasonal variations in malaria transmission in semi-immune children, antibiody levels remain stable in clncall immine adults.

Keywords: cytokine receptors; IL-2, IL-5, phosphorylation; signal transduction

Journal Article.  0 words. 

Subjects: Immunology ; Biological Sciences

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