Journal Article

Lung inflammation stalls T<sub>h</sub>17-cell migration <i>en route</i> to the central nervous system during the development of experimental autoimmune encephalomyelitis

Masashi Kanayama, Keiko Danzaki, You-Wen He and Mari L. Shinohara

in International Immunology

Volume 28, issue 9, pages 463-469
Published in print September 2016 | ISSN: 0953-8178
Published online March 2016 | e-ISSN: 1460-2377 | DOI: http://dx.doi.org/10.1093/intimm/dxw013
Lung inflammation stalls Th17-cell migration en route to the central nervous system during the development of experimental autoimmune encephalomyelitis

More Like This

Show all results sharing these subjects:

  • Immunology
  • Biological Sciences

GO

Show Summary Details

Preview

Recruiting pathogenic T cells to the central nervous system (CNS) is a critical step during the development of experimental autoimmune encephalomyelitis (EAE). Here, we report that the absence of autophagy and microtubule-associated protein 1A/1B-light chain 3-associated phagocytosis significantly delayed the onset of EAE in Atg7 conditional knockout (Atg7 CKO) mice in myeloid cells. T-helper cell-cell priming appeared to be normal in the Atg7 CKO mice, but the mice showed significant accumulation of Th17 cells in the lung. The data suggested that the stalling of Th17 cells in the lung en route to the CNS caused the delay. The lung of Atg7 CKO mice, in which we previously demonstrated spontaneous mild inflammation, showed high expression of CCL20, a chemokine that attracts Th17 cells. We have also shown that LPS intranasal instillation delayed EAE onset, suggesting that pulmonary inflammation has an impact on EAE development. Based on our data, therapeutic immunomodulation targeted to the lung, rather than systemically, might be a possible future option to treat multiple sclerosis.

Keywords: autoimmunity; autophagy; CCL20; T-cell recruitment

Journal Article.  4049 words.  Illustrated.

Subjects: Immunology ; Biological Sciences

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.