Journal Article

Clarithromycin resistance stability in <i>Helicobacter pylori</i>: influence of the MIC and type of mutation in the 23S rRNA

Teresa Alarcón, Diego Domingo, Nuria Prieto and Manuel López-Brea

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 46, issue 4, pages 613-616
Published in print October 2000 | ISSN: 0305-7453
Published online October 2000 | e-ISSN: 1460-2091 | DOI:
Clarithromycin resistance stability in Helicobacter pylori: influence of the MIC and type of mutation in the 23S rRNA

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Thirty clarithromycin-resistant Helicobacter pylori strains (MIC range 8–64 mg/L) were subcultured in a drug-free medium and the MIC was determined every five passages to detect in vitro stability of resistance. Three out of the 30 (10%) lost their resistance after 10, 13 or 18 subcultures (MIC decrease from 8 to 0.008, from 16 to 0.064 and from 32 to 0.016 mg/L). The effect of four macrolides at subinhibitory concentrations on the development of resistance was studied in H. pylori NCTC 11638 and TIGR 26695. A change in the MIC was observed only when NCTC11638 was exposed to 0.5 × MIC of erythromycin for 20 days.

Journal Article.  2051 words. 

Subjects: Medical Oncology ; Critical Care

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