Journal Article

Susceptibility of <i>Yersinia pestis</i> to novel and conventional antimicrobial agents

John Frean, Keith P. Klugman, Lorraine Arntzen and Stanley Bukofzer

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 52, issue 2, pages 294-296
Published in print August 2003 | ISSN: 0305-7453
Published online August 2003 | e-ISSN: 1460-2091 | DOI: http://dx.doi.org/10.1093/jac/dkg363
 Susceptibility of Yersinia pestis to novel and conventional antimicrobial agents

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Objectives: To determine the susceptibility of southern African strains of Yersinia pestis to novel as well as conventional antimicrobial agents.

Materials and methods: The MICs of 28 strains of Yersinia pestis from a southern African plague focus were determined by agar dilution.

Results: The most active agents were cefditoren and the fluoroquinolones, both conventional and novel. The in vitro activity of macrolides was poor against this member of the Enterobacteriaceae.

Conclusion: Further investigation of the novel quinolones olamufloxacin (HSR 903) and ABT 492 in animal models of plague would seem to be justified.

Keywords: Keywords: plague, antibiotics, fluoroquinolones, macrolides, ketolides

Journal Article.  1422 words. 

Subjects: Medical Oncology ; Critical Care

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