Journal Article

Susceptibility of <i>Bacillus anthracis</i> to eleven antimicrobial agents including novel fluoroquinolones and a ketolide

John Frean, Keith P. Klugman, Lorraine Arntzen and Stanley Bukofzer

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 52, issue 2, pages 297-299
Published in print August 2003 | ISSN: 0305-7453
Published online August 2003 | e-ISSN: 1460-2091 | DOI: http://dx.doi.org/10.1093/jac/dkg364
Susceptibility of Bacillus anthracis to eleven antimicrobial agents including novel fluoroquinolones and a ketolide

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Objectives: To determine the susceptibility of southern African strains of Bacillus anthracis to new, investigational agents as well as conventional antibiotics.

Materials and methods: The MICs of 26 isolates of B. anthracis from South Africa and Zimbabwe, as well as the Sterne vaccine strain and a type culture strain, were determined by agar dilution.

Results: The most active antimicrobial agents were the novel ketolide ABT 773, new and conventional fluoroquinolones, and doxycycline; macrolides were intermediately active. The lack of activity of extended-spectrum cephalosporins against B. anthracis was confirmed.

Conclusions: Susceptibility to conventional antibiotics was in keeping with previous studies. Two new fluoroquinolones and a ketolide showed promising in vitro activity that would support their further evaluation in animal models of anthrax.

Keywords: Keywords: anthrax, antibiotics, fluoroquinolones, macrolides, ketolides

Journal Article.  1470 words. 

Subjects: Medical Oncology ; Critical Care

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