Journal Article

<i>In vitro</i> activity of cethromycin, a novel antibacterial ketolide, against <i>Chlamydia pneumoniae</i>

Naoyuki Miyashita, Hiroshi Fukano, Koichiro Yoshida, Yoshihito Niki and Toshiharu Matsushima

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 52, issue 3, pages 497-499
Published in print September 2003 | ISSN: 0305-7453
Published online September 2003 | e-ISSN: 1460-2091 | DOI: http://dx.doi.org/10.1093/jac/dkg371
In vitro activity of cethromycin, a novel antibacterial ketolide, against Chlamydia pneumoniae

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Objectives: To investigate the in vitro activity of cethromycin, a new ketolide, against Chlamydia pneumoniae.

Methods: The in vitro activity of cethromycin against 20 isolates of C. pneumoniae was compared with the activities of telithromycin, erythromycin A, azithromycin and clarithromycin against those isolates.

Results: The MIC at which 90% of the isolates were inhibited and the minimal chlamydiacidal concentration at which 90% of the isolates were killed by cethromycin were both 0.016 mg/L (range 0.016–0.031 mg/L). Cethromycin was the most active antibiotic tested in this study.

Conclusions: Our results appear to indicate that cethromycin is an effective antibiotic that should play some role in the treatment of respiratory tract infections caused by C. pneumoniae.

Keywords: Keywords: macrolides, telithromycin, community-acquired pneumonia

Journal Article.  1700 words.  Illustrated.

Subjects: Medical Oncology ; Critical Care

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