Journal Article

Activity of faropenem and imipenem for ciprofloxacin-resistant bacteria

Laura J. V. Piddock, M. M. Johnson and Mark A. Webber

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 52, issue 3, pages 500-502
Published in print September 2003 | ISSN: 0305-7453
Published online September 2003 | e-ISSN: 1460-2091 | DOI:
Activity of faropenem and imipenem for ciprofloxacin-resistant bacteria

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Aim: To determine whether an association exists between ciprofloxacin and faropenem resistance in bacteria including multiply drug-resistant isolates.

Methods: The MICs were determined for 150 fluoroquinolone-resistant bacteria, plus 20 nalidixic acid-resistant strains of Salmonella enterica serovar Typhimurium.

Results: Faropenem was very active against Escherichia coli and Streptococcus pneumoniae, but 5/31 Staphylococcus aureus and 2/26 Bacteroides fragilis required ≥16 mg/L for inhibition. Of 30 multiply drug-resistant isolates with a phenotype suggestive of enhanced efflux, only for one strain (a Bacteroides fragilis) was the faropenem MIC higher than that associated with the other isolates of the same species.

Conclusions: Faropenem was in general as active as imipenem. There was no association between resistance to ciprofloxacin and faropenem or imipenem resistance.

Keywords: Keywords: carbapenem, fluoroquinolone, MIC

Journal Article.  1835 words. 

Subjects: Medical Oncology ; Critical Care

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