Journal Article

Relationships among various nucleoside resistance-conferring mutations in the reverse transcriptase of HIV-1

Dan Turner, Bluma Brenner and Mark A. Wainberg

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 53, issue 1, pages 53-57
Published in print January 2004 | ISSN: 0305-7453
Published online January 2004 | e-ISSN: 1460-2091 | DOI: http://dx.doi.org/10.1093/jac/dkh009
Relationships among various nucleoside resistance-conferring mutations in the reverse transcriptase of HIV-1

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Highly active antiretroviral therapy has significantly improved HIV-related morbidity and mortality, and nucleoside reverse transcriptase inhibitors remain an essential component of treatment. However, the emergence of HIV-1 mutated strains that are resistant to one or more antiretroviral drugs is a leading cause of treatment failure among patients living with HIV/AIDS. These resistant strains may often suffer from a replication disadvantage in comparison with wild-type viruses when grown in the absence of drug pressure and a potential benefit in this regard has been shown for lamivudine-resistant viruses that contain a M184V mutation in reverse transcriptase, as well as for several other drug-resistant viral variants. Interactions between different mutations may complicate the understanding of HIV drug resistance with regard to the likelihood of therapeutic success.

Keywords: Keywords: HIV, NRTIs, resistance, mutations, antiretroviral drugs, nucleosides, diminished sensitivity, viral fitness

Journal Article.  4652 words. 

Subjects: Medical Oncology ; Critical Care

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