Journal Article

Available clinical markers of treatment outcome integrated in mathematical models to guide therapy in HIV infection

Elisabeta Vergu, Alain Mallet and Jean-Louis Golmard

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 53, issue 2, pages 140-143
Published in print February 2004 | ISSN: 0305-7453
Published online February 2004 | e-ISSN: 1460-2091 | DOI: http://dx.doi.org/10.1093/jac/dkh024
Available clinical markers of treatment outcome integrated in mathematical models to guide therapy in HIV infection

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Because treatment failure in many HIV-infected persons may be due to multiple causes, including resistance to antiretroviral agents, it is important to better tailor drug therapy to individual patients. This improvement requires the prediction of treatment outcome from baseline immunological or virological factors, and from results of resistance tests. Here, we review briefly the available clinical factors that have an impact on therapy outcome, and discuss the role of a predictive modelling approach integrating these factors proposed in a previous work. Mathematical and statistical models could become essential tools to address questions that are difficult to study clinically and experimentally, thereby guiding decisions in the choice of individualized drug regimens.

Keywords: Keywords: resistance tests, modelling, therapy outcome

Journal Article.  3658 words.  Illustrated.

Subjects: Medical Oncology ; Critical Care

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