Journal Article

Clonal dissemination of mupirocin-resistant staphylococci in Greek hospitals

E. Petinaki, I. Spiliopoulou, F. Kontos, M. Maniati, Z. Bersos, N. Stakias, H. Malamou-Lada, Ch. Koutsia-Carouzou and A. N. Maniatis

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 53, issue 1, pages 105-108
Published in print January 2004 | ISSN: 0305-7453
Published online January 2004 | e-ISSN: 1460-2091 | DOI: http://dx.doi.org/10.1093/jac/dkh028
Clonal dissemination of mupirocin-resistant staphylococci  in Greek hospitals

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Objectives: To determine the rates of mupirocin resistance in staphylococci during a 4 year period (1999–2002) in Greece.

Materials: A total of 1200 Staphylococcus aureus and 2760 coagulase-negative staphylococci (CoNS), consecutively collected from four Greek hospitals located in different geographical areas, were tested for susceptibility to mupirocin using the Etest and a reference agar dilution method.

Results: Twenty-four S. aureus (2%) and 532 CoNS (19.2%) were found to be mupirocin-resistant during the study period. High-level mupirocin resistance was detected in 20 S. aureus (1.6%) and in 440 CoNS (15.9%), respectively. No variations in the rates of mupirocin-resistant S. aureus in relation to the year of collection were observed. In contrast, the rate of mupirocin-resistant CoNS increased dramatically from 9% in 1999, to 14% in 2000, 20% in 2001 and reached 33% in 2002. PFGE analysis revealed the presence of one main clone (A) among mupirocin-resistant S. aureus and two main clones (i and a) among Staphylococcus epidermidis isolates.

Conclusions: In Greece, the rate of mupirocin-resistant S. aureus has remained low and steady since 1999. The high rate of mupirocin-resistant CoNS (33%) in 2002 was due mainly to clonal dissemination of epidemic hospital clones.

Keywords: Keywords: Staphylococcus aureus, Staphylococcus epidermidis, mupirocin resistance, epidemic clones, Greece

Journal Article.  2285 words.  Illustrated.

Subjects: Medical Oncology ; Critical Care

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