Journal Article

Trends in the treatment of orthopaedic prosthetic infections

Louis Bernard, Pierre Hoffmeyer, Mathieu Assal, Pierre Vaudaux, Jacques Schrenzel and Daniel Lew

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 53, issue 2, pages 127-129
Published in print February 2004 | ISSN: 0305-7453
Published online February 2004 | e-ISSN: 1460-2091 | DOI:
Trends in the treatment of orthopaedic prosthetic infections

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The most commonly used therapy for prosthetic joint infection is a two-stage prosthetic exchange separated by 6 weeks of intravenous antibiotic therapy. This often results in long periods of hospitalization, morbidity, severe functional impairment and sometimes increased mortality. Therefore novel and challenging therapeutic approaches have been attempted, particularly in hip prosthetic infection. This includes, whenever possible, according to the type of microorganism, antibacterial susceptibility and clinical presentation (including age and comorbidities): (i) less aggressive surgical techniques (debridement and prosthesis retention, or re-implantation with a single-stage exchange arthroplasty); and (ii) antibiotic combinations active against biofilm-associated bacteria, including rifampicin (particularly with quinolones) with excellent bio-availability which allow prolonged and efficient oral therapy.

Keywords: Keywords: total joint infection, exchange prosthesis, one-stage prosthetic reimplantation, two-stage prosthetic reimplantation

Journal Article.  2655 words. 

Subjects: Medical Oncology ; Critical Care

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