Journal Article

Persistence of a clone of glycopeptide-resistant <i>Enterococcus faecalis</i> among patients in an intensive care unit of a Greek hospital

Spyros Pournaras, Helen Malamou-Lada, Maria Maniati, Dimitra Mylona-Petropoulou, Helen Vagiakou-Voudris, Athanassios Tsakris and Antonios N. Maniatis

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 53, issue 1, pages 109-112
Published in print January 2004 | ISSN: 0305-7453
Published online January 2004 | e-ISSN: 1460-2091 | DOI:
Persistence of a clone of glycopeptide-resistant Enterococcus faecalis among patients in an intensive care unit of a Greek hospital

More Like This

Show all results sharing these subjects:

  • Medical Oncology
  • Critical Care


Show Summary Details


Objectives: To investigate an outbreak of glycopeptide-resistant Enterococcus faecalis (GREF) in the intensive care unit (ICU) of ‘G. Gennimatas’ General Hospital, Athens, Greece.

Materials and methods: Between August 2000 and November 2001, 20 highly GREF isolates were recovered from severe infections of separate patients in the ICU. The isolates were tested by PCR, PFGE, mating experiments and plasmid analysis.

Results: All isolates carried the vanA gene. Nineteen isolates fitted to one clone by macrorestriction analysis with four subclones being consecutively detected. Each subclone seemed to predominate for a specific time period. Additionally, four GREF isolates related to the ICU clone were recovered from other wards of the hospital.

Conclusions: Our findings indicate that a monoclonal GREF outbreak persisted for more than 1 year in a large Greek hospital. The rate of GREF isolation declined after the application of infection control measures.

Keywords: Keywords: glycopeptide resistance, Enterococcus faecalis clone, outbreak

Journal Article.  2322 words.  Illustrated.

Subjects: Medical Oncology ; Critical Care

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.