Journal Article

<i>In vitro</i> antibacterial activity of the peptide PsVP-10 against antimicrobial-resistant <i>Enterococcus faecalis</i> isolated from clinical samples

C. Padilla, O. Lobos, P. Brevis, P. Abaca and E. Hubert

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 53, issue 2, pages 390-392
Published in print February 2004 | ISSN: 0305-7453
Published online February 2004 | e-ISSN: 1460-2091 | DOI: http://dx.doi.org/10.1093/jac/dkh067
In vitro antibacterial activity of the peptide PsVP-10 against antimicrobial-resistant Enterococcus faecalis isolated from clinical samples

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  • Medical Oncology
  • Critical Care

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Objective: To analyse the antimicrobial activity of the peptide PsVP-10 against 67 resistant Enterococcus faecalis strains isolated from clinical samples.

Methods: The qualitative disc diffusion method and MIC determinations were used.

Results: The presence of several multidrug-resistant phenotypes of E. faecalis was demonstrated, in which there were high MICs to chloramphenicol, tetracycline, vancomycin, cefaloridine, ampicillin and gentamicin. In comparison, the peptide PsVP-10 showed lower MICs against all the multidrug-resistant and susceptible E. faecalis.

Conclusions: There is an urgent need for the development of novel antimicrobial agents against the highly resistant E. faecalis. The present study shows that the peptide PsVP-10 might make a contribution to the solution of this serious problem.

Keywords: Keywords: antibiotics, multiresistance and human infections

Journal Article.  1295 words. 

Subjects: Medical Oncology ; Critical Care

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