Journal Article

Tissue kinetics of telithromycin, the first ketolide antibacterial

C. Muller-Serieys, J. Andrews, F. Vacheron and C. Cantalloube

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 53, issue 2, pages 149-157
Published in print February 2004 | ISSN: 0305-7453
Published online February 2004 | e-ISSN: 1460-2091 | DOI:
Tissue kinetics of telithromycin, the first ketolide antibacterial

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The potential efficacy of an antibacterial depends not only on its spectrum of activity but also on its concentration at the site of infection. The tissue kinetics of telithromycin—the first ketolide antibacterial—are reviewed here. Telithromycin accumulates rapidly in white blood cells, inflammatory fluid, and cells and tissues of the upper and lower respiratory tract, with mean concentrations above the MICs of key respiratory pathogens. Tissue kinetics of telithromycin support facilitated delivery to the site of infection, good efficacy against intracellular respiratory pathogens and respiratory pathogens at extracellular sites in the airways, and effectiveness in the treatment of upper and lower respiratory tract infections (RTIs). The tissue kinetics profile of telithromycin, together with its microbiological profile, makes it a promising new antibacterial for the treatment of community-acquired RTIs.

Keywords: Keywords: antibacterial, ketolide, telithromycin, tissue kinetics

Journal Article.  6319 words.  Illustrated.

Subjects: Medical Oncology ; Critical Care

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