Journal Article

Caspofungin modulates <i>in vitro</i> adherence of <i>Candida albicans</i> to plastic coated with extracellular matrix proteins

Jérôme Soustre, Marie-Hélène Rodier, Sabrina Imbert-Bouyer, Gyslaine Daniault and Christine Imbert

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 53, issue 3, pages 522-525
Published in print March 2004 | ISSN: 0305-7453
Published online March 2004 | e-ISSN: 1460-2091 | DOI: http://dx.doi.org/10.1093/jac/dkh099
Caspofungin modulates in vitro adherence of Candida albicans to plastic coated with extracellular matrix proteins

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Objectives: Some manifestations of candidiasis are associated with the formation of biofilms on inert or biological surfaces and the intrinsic resistance of Candida albicans biofilms to the most commonly used antifungal agents has been demonstrated. In this study, we report on the influence of the growth of C. albicans in medium containing a sub-inhibitory concentration (MIC/2) of caspofungin, on subsequent fungal adherence to plastic coated with extracellular matrix (ECM) proteins.

Methods: Eleven strains of C. albicans were studied: six strains were susceptible to fluconazole in vitro and five strains were resistant to this antifungal agent.

Results: Caspofungin induced a decrease in the adherence of all the tested strains that were susceptible to fluconazole but induced a decrease in the adherence of only 60% of the fluconazole-resistant strains.

Conclusions: This study demonstrated the anti-adherent activity of caspofungin but indicated a reduced effect in the case of in vitro fluconazole resistance. These results indicated a possible relationship between the efficiency of caspofungin to inhibit the first step of the development of C. albicans biofilm and the resistance of C. albicans to fluconazole in vitro.

Keywords: Keywords: yeast, adhesion, antifungal agents, candidiasis

Journal Article.  2132 words.  Illustrated.

Subjects: Medical Oncology ; Critical Care

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