Journal Article

Macrolide resistance and genotypic characterization of <i> Streptococcus pneumoniae</i> in Asian countries: a study of the Asian Network for Surveillance of Resistant Pathogens (ANSORP)

Jae-Hoon Song, Hyun-Ha Chang, Ji Yoeun Suh, Kwan Soo Ko, Sook-In Jung, Won Sup Oh, Kyong Ran Peck, Nam Yong Lee, Yonghong Yang, Anan Chongthaleong, Nalinee Aswapokee, Cheng-Hsun Chiu, M. K. Lalitha, Jennifer Perera, Ti Teow Yee, Gamini Kumararasinghe, Farida Jamal, Adeeba Kamarulazaman, Navaratnam Parasakthi, Pham Hung Van, Thomas So and Tak Keung Ng

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 53, issue 3, pages 457-463
Published in print March 2004 | ISSN: 0305-7453
Published online March 2004 | e-ISSN: 1460-2091 | DOI: http://dx.doi.org/10.1093/jac/dkh118
Macrolide resistance and genotypic characterization of  Streptococcus pneumoniae in Asian countries: a study of the Asian Network for Surveillance of Resistant Pathogens (ANSORP)

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  • Medical Oncology
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Objectives: To characterize mechanisms of macrolide resistance among Streptococcus pneumoniae from 10 Asian countries during 1998–2001.

Methods: Phenotypic and genotypic characterization of the isolates and their resistance mechanisms.

Results: Of 555 isolates studied, 216 (38.9%) were susceptible, 10 (1.8%) were intermediate and 329 (59.3%) were resistant to erythromycin. Vietnam had the highest prevalence of erythromycin resistance (88.3%), followed by Taiwan (87.2%), Korea (85.1%), Hong Kong (76.5%) and China (75.6%). Ribosomal methylation encoded by erm(B) was the most common mechanism of erythromycin resistance in China, Taiwan, Sri Lanka and Korea. In Hong Kong, Singapore, Thailand and Malaysia, efflux encoded by mef(A) was the more common in erythromycin-resistant isolates. In most Asian countries except Hong Kong, Malaysia and Singapore, erm(B) was found in >50% of pneumococcal isolates either alone or in combination with mef(A). The level of erythromycin resistance among pneumococcal isolates in most Asian countries except Thailand and India was very high with MIC90s of >128 mg/L. Molecular epidemiological studies suggest the horizontal transfer of the erm(B) gene and clonal dissemination of resistant strains in the Asian region.

Conclusion: Data confirm that macrolide resistance in pneumococci is a serious problem in many Asian countries.

Keywords: Keywords: erythromycin, erm(B), mef(A), pneumococci

Journal Article.  4311 words.  Illustrated.

Subjects: Medical Oncology ; Critical Care

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